Conundrum of IP6

Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma.

We characterized the effect of phytic acid (inositol hexaphosphate, IP6) as a potential adjuvant in treatment of colorectal carcinoma and evaluated the optimal concentration and treatment time to produe the maximal therapeutic effect. There is some evidence that myoinositol (Ins) can potentiate anti-cancer effects of IP6. Therefore, we tested both IP6 and Ins individually and in combination on ...

Differential response of MC3T3-E1 and human mesenchymal stem cells to inositol hexakisphosphate.

BACKGROUND Inositol hexakisphosphate (IP6) has been found to have an important role in biomineralization. METHODS Because the complete mechanism of action of IP6 on osteoblasts is not fully understood and its potential use in the primary prevention of osteoporosis, we examined the direct effect of IP6 on cell viability and differentiation of MC3T3-E1 cells and on differentiation of human umbi...

Role of protein tyrosine kinase in the effect of IP6 on IL-8 secretion in intestinal epithelial cells.

Phytic acid (IP6) is a major fiber-associated component of a diet physiologically present in human intestines. Studies showed that this phytochemical can modulate immune functions of intestinal epithelium through regulation of proinflammatory cytokines secretion but mechanisms underlying these cellular response to IP6 have weakly been examined, as yet. The aim of this study was to determine the...

Phytic acid and phytase: implications for protein utilization by poultry.

The effect of the ingestion of myo-inositol hexaphosphate (IP6) and phytase (EC 3.1.3.26) on the digestibility of casein was investigated using growing broiler chickens. A total of 64 female Ross broilers were used in a precision feeding study. One group of 8 birds was fed a solution of glucose to estimate endogenous losses. Seven groups, each of 8 birds, were fed either casein, casein + 1,000 ...

THE CONUNDRUM OF EUTHANASIA